Forces in Tissue Morphogenesis and Patterning | Zendy

CarlPhilipp Heisenberg | Zendy; Yohanns Bellaı̈che | Zendy

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Forces in Tissue Morphogenesis and Patterning

Author(s) -

CarlPhilipp Heisenberg,

Yohanns Bellaı̈che

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.05.008

Subject(s) - morphogenesis , biology , myosin , microbiology and biotechnology , actin , cell fate determination , genetics , gene , transcription factor

During development, mechanical forces cause changes in size, shape, number, position, and gene expression of cells. They are therefore integral to any morphogenetic processes. Force generation by actin-myosin networks and force transmission through adhesive complexes are two self-organizing phenomena driving tissue morphogenesis. Coordination and integration of forces by long-range force transmission and mechanosensing of cells within tissues produce large-scale tissue shape changes. Extrinsic mechanical forces also control tissue patterning by modulating cell fate specification and differentiation. Thus, the interplay between tissue mechanics and biochemical signaling orchestrates tissue morphogenesis and patterning in development.

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