Open AccessSynovial Sarcoma Mechanisms: A Series of Unfortunate Events
Author(s) -
Jesper Q. Svejstrup
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.03.015
Subject(s) - synovial sarcoma , biology , chromosomal translocation , microbiology and biotechnology , function (biology) , transformation (genetics) , dna , chromosome , sarcoma , genetics , computational biology , gene , pathology , medicine
Human synovial sarcoma is caused by a chromosome translocation, which fuses DNA encoding SSX to that encoding the SS18 protein. Kadoch and Crabtree now show that the resulting cellular transformation stems from disruption of the normal architecture and function of the human SWI/SNF (BAF) complex.
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