Open AccessA Tollgate for Typhoid
Author(s) -
Ferric C. Fang,
Andreas J. Bäumler
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.10.016
Subject(s) - typhoid fever , biology , salmonella enterica , salmonella typhi , virology , immunology , immunity , salmonella , immune system , gene , bacteria , genetics , escherichia coli
Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enterica serovar Typhi. Mathur et al. now report that mice lacking Toll-like receptor 11, which is absent in humans, can be lethally infected with S. Typhi, a breakthrough that promises to speed the development of better vaccines.
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