All Things to All People
Author(s) -
Trevor D. Littlewood,
Peter Kreuzaler,
Gérard I. Evan
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.09.006
Subject(s) - biology , leucine zipper , ectopic expression , gene , transcription factor , context (archaeology) , proto oncogene proteins c myc , microbiology and biotechnology , somatic cell , basic helix loop helix , genetics , transcription (linguistics) , dna binding protein , cancer research , paleontology , linguistics , philosophy
Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.
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