Open AccessDiabetic β Cells: To Be or Not To Be?
Author(s) -
Sapna Puri,
Matthias Hebrok
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.08.021
Subject(s) - biology , mechanism (biology) , apoptosis , diabetes mellitus , insulin , cell , type 2 diabetes , bioinformatics , microbiology and biotechnology , endocrinology , genetics , philosophy , epistemology
β cell dysfunction with subsequent apoptosis is considered a significant contributor to the development of type 2 diabetes. Emerging data from Talchai et al. suggest β cell dedifferentiation as an alternative mechanism of insulin insufficiency that might be more amenable to intervention in at least a subset of patients.
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