A Bistable Circuit Involving SCARECROW-RETINOBLASTOMA Integrates Cues to Inform Asymmetric Stem Cell Division | Zendy

Alfredo CruzRamírez | Zendy; Sara Diaz Trivino | Zendy; Ikram Blilou | Zendy; Verônica A. Grieneisen | Zendy; Rosangela Sozzani | Zendy; Christos Zamioudis | Zendy; Pál Miskolczi | Zendy; Jeroen Nieuwland | Zendy; René Benjamins | Zendy; Pankaj Dhonukshe | Zendy; Juan Caballero-Pérez | Zendy; Beátrix Horváth | Zendy; Yuchen Long | Zendy; Ari Pekka Mähönen | Zendy; Hongtao Zhang | Zendy; Jian Xu | Zendy; J. A. H. Murray | Zendy; Philip N. Benfey | Zendy; László Bakó | Zendy; Athanasius F. M. Marée | Zendy; Ben Scheres | Zendy

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A Bistable Circuit Involving SCARECROW-RETINOBLASTOMA Integrates Cues to Inform Asymmetric Stem Cell Division

Author(s) -

Alfredo CruzRamírez,

Sara Diaz Trivino,

Ikram Blilou,

Verônica A. Grieneisen,

Rosangela Sozzani,

Christos Zamioudis,

Pál Miskolczi,

Jeroen Nieuwland,

René Benjamins,

Pankaj Dhonukshe,

Juan Caballero-Pérez,

Beátrix Horváth,

Yuchen Long,

Ari Pekka Mähönen,

Hongtao Zhang,

Jian Xu,

J. A. H. Murray,

Philip N. Benfey,

László Bakó,

Athanasius F. M. Marée,

Ben Scheres

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.07.017

Subject(s) - biology , stem cell , retinoblastoma , cell division , bistability , microbiology and biotechnology , asymmetric cell division , division (mathematics) , neuroscience , cell , genetics , gene , optoelectronics , physics , arithmetic , mathematics

In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOMA-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a "flip flop" that constrains asymmetric cell division to the stem cell region.

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