Open AccessTumor Suppression by p53: Fall of the Triumvirate?
Author(s) -
Andreas Hock,
Karen H. Vousden
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.05.024
Subject(s) - biology , suppressor , senescence , apoptosis , cell cycle checkpoint , mode of action , cell cycle , cancer research , microbiology and biotechnology , tumor suppressor gene , genetics , gene , carcinogenesis , toxicology
p53 is a key tumor suppressor protein that has numerous functions. Its primary mode of action has generally been ascribed to the induction of cell-cycle arrest, apoptosis, or senescence upon stress. Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressive role.
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