Open AccessFeeling the Squeeze: Live-Cell Extrusion Limits Cell Density in Epithelia
Author(s) -
Rodrigo FernándezGonzález,
Jennifer A. Zallen
Publication year - 2012
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2012.05.006
Subject(s) - biology , extrusion , cell , feeling , microbiology and biotechnology , genetics , social psychology , psychology , materials science , metallurgy
Tissues develop in confined volumes that can impose mechanical constraints on their growth, but it is unclear how cells respond to these limits to regulate tissue size and shape. Two papers show that overcrowding and cell deformation lead to the shedding of live cells to maintain homeostasis in epithelial cell sheets
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