Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock | Zendy

Thomas A. Rando | Zendy; Howard Y. Chang | Zendy

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Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

Author(s) -

Thomas A. Rando,

Howard Y. Chang

Publication year - 2012

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2012.01.003

Subject(s) - biology , reprogramming , rejuvenation , epigenetics , cellular aging , epigenesis , cellular senescence , genetics , microbiology and biotechnology , dna methylation , telomere , phenotype , dna , gene expression , cell , gene

The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges.

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