Open AccessThe Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine
Author(s) -
Luke O'neill,
Andrew Bowie
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.09.027
Subject(s) - biology , rig i , innate immune system , rna silencing , rna , interferon , virology , mda5 , immune system , computational biology , rna interference , gene , genetics
The innate immune sensor RIG-I responds to infection by binding to viral double-stranded RNA (dsRNA). In this issue of Cell, Kowalinski et al. (2011) and Luo et al. (2011) reveal the structure of RIG-I, and in combination with functional analyses, they show how RIG-I recognizes viral RNA to initiate signaling and a type I interferon response.
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