When T Cells Run Out of Breath: The HIF-1α Story | Zendy

Katherine Nutsch | Zendy; Chyi S. Hsieh | Zendy

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When T Cells Run Out of Breath: The HIF-1α Story

Author(s) -

Katherine Nutsch,

Chyi S. Hsieh

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.08.018

Subject(s) - biology , inflammation , transcription factor , hypoxia (environmental) , immunology , microbiology and biotechnology , cancer research , bioinformatics , genetics , gene , chemistry , organic chemistry , oxygen

In this issue, Dang et al. (2011) report a role for the hypoxia-induced transcription factor HIF-1α in regulating the differentiation of T cell subsets that impact both inflammation and its resolution. Their findings illustrate how metabolic signals can alter the balance between inflammation and tolerance and present a potential therapeutic opportunity for the treatment of diseases associated with chronic inflammation.

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