Mechanisms for the Inheritance of Chromatin States | Zendy

Danesh Moazed | Zendy

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Mechanisms for the Inheritance of Chromatin States

Author(s) -

Danesh Moazed

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.07.013

Subject(s) - biology , chromatin , epigenetics , genetics , histone , multicellular organism , dna replication , bivalent chromatin , dna , nucleosome , microbiology and biotechnology , gene

Studies in eukaryotes ranging from yeast to mammals indicate that specific chromatin structures can be inherited following DNA replication via mechanisms acting in cis. Both the initial establishment of such chromatin structures and their inheritance require sequence-dependent specificity factors and changes in histone posttranslational modifications. Here I propose models for the maintenance of epigenetic information in which DNA silencers or nascent RNA scaffolds act as sensors that work cooperatively with parentally inherited histones to re-establish chromatin states following DNA replication.

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