Estrogen Receptor Transrepresses Brain Inflammation | Zendy

David Gosselin | Zendy; Serge Rivest | Zendy

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Estrogen Receptor Transrepresses Brain Inflammation

Author(s) -

David Gosselin,

Serge Rivest

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2011.04.018

Subject(s) - biology , inflammation , multiple sclerosis , estrogen , estrogen receptor , transrepression , disease , receptor , bioinformatics , cancer research , immunology , neuroscience , endocrinology , medicine , genetics , cancer , breast cancer , gene , transactivation , transcription factor

Estrogen receptors (ERs) have long been implicated in the etiology of multiple sclerosis, but no clear molecular mechanisms have linked ERs to the disease's pathology. Now Saijo et al. (2011) provide evidence that ERβ activates a transrepression pathway that suppresses inflammation and inhibits progression of pathology in a mouse model of multiple sclerosis.

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