Open AccessRallying the Exocyst as an Autophagy Scaffold
Author(s) -
JeanClaude Farré,
Suresh Subramani
Publication year - 2011
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2011.01.005
Subject(s) - biology , exocyst , autophagy , scaffold , microbiology and biotechnology , computational biology , evolutionary biology , genetics , gene , engineering , apoptosis , protein subunit , biomedical engineering
Protein scaffolds coordinate the assembly of many multicomponent signaling complexes. Bodemann et al. (2011) now show that the exocyst, a protein complex involved in tethering transport vesicles to the plasma membrane, provides an assembly and activation platform for components of the autophagy machinery via a process requiring the GTPase RalB.
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