Regulation of Mitochondrial Protein Import by Cytosolic Kinases | Zendy

Oliver Schmidt | Zendy; Angelika B. Harbauer | Zendy; Sanjana Rao | Zendy; Beate Eyrich | Zendy; René P. Zahedi | Zendy; Diana Stojanovski | Zendy; Birgit Schönfisch | Zendy; Bernard Guiard | Zendy; Albert Sickmann | Zendy; Nikolaus Pfanner | Zendy; Chris Meisinger | Zendy

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Regulation of Mitochondrial Protein Import by Cytosolic Kinases

Author(s) -

Oliver Schmidt,

Angelika B. Harbauer,

Sanjana Rao,

Beate Eyrich,

René P. Zahedi,

Diana Stojanovski,

Birgit Schönfisch,

Bernard Guiard,

Albert Sickmann,

Nikolaus Pfanner,

Chris Meisinger

Publication year - 2011

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.12.015

Subject(s) - biology , microbiology and biotechnology , mitochondrion , cytosol , translocase of the outer membrane , biochemistry , casein kinase 1 , mitochondrial biogenesis , atp–adp translocase , translocase , protein phosphorylation , phosphorylation , translocase of the inner membrane , autophagy related protein 13 , protein kinase a , casein kinase 2 , mitochondrial membrane transport protein , kinase , inner mitochondrial membrane , mitogen activated protein kinase kinase , enzyme , chromosomal translocation , gene

Mitochondria import a large number of nuclear-encoded proteins via membrane-bound transport machineries; however, little is known about regulation of the preprotein translocases. We report that the main protein entry gate of mitochondria, the translocase of the outer membrane (TOM complex), is phosphorylated by cytosolic kinases-in particular, casein kinase 2 (CK2) and protein kinase A (PKA). CK2 promotes biogenesis of the TOM complex by phosphorylation of two key components, the receptor Tom22 and the import protein Mim1, which in turn are required for import of further Tom proteins. Inactivation of CK2 decreases the levels of the TOM complex and thus mitochondrial protein import. PKA phosphorylates Tom70 under nonrespiring conditions, thereby inhibiting its receptor activity and the import of mitochondrial metabolite carriers. We conclude that cytosolic kinases exert stimulatory and inhibitory effects on biogenesis and function of the TOM complex and thus regulate protein import into mitochondria.

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