Open AccessInsulin Signaling: Inositol Phosphates Get into the Akt
Author(s) -
Brendan D. Manning
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.11.040
Subject(s) - biology , inositol , protein kinase b , insulin receptor , insulin , proto oncogene proteins c akt , signal transduction , microbiology and biotechnology , biochemistry , endocrinology , receptor , insulin resistance
An acute but transient response to insulin is essential for glucose homeostasis in mammals. Chakraborty et al. (2010) uncover a new feedback mechanism regulating insulin signaling. They show that the inositol pyrophosphate IP7, which is produced in response to insulin, inhibits the Akt kinase, a primary effector of insulin signaling.
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