Open AccessSIRT3 in Calorie Restriction: Can You Hear Me Now?
Author(s) -
Carlos Sebastián,
Raúl Mostoslavsky
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.11.009
Subject(s) - sirt3 , calorie restriction , sirtuin , biology , caloric theory , forebrain , isocitrate dehydrogenase , idh2 , histone , genetics , acetylation , endocrinology , medicine , gene , biochemistry , idh1 , enzyme , mutation , central nervous system
Caloric restriction decreases oxidative damage and extends life span in many organisms. Someya et al. (2010) show that the sirtuin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promoting the mitochondrial antioxidant system through the regulation of isocitrate dehydrogenase 2 (Idh2).
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