Open AccessWhat Determines the Specificity and Outcomes of Ubiquitin Signaling?
Author(s) -
Fumiyo Ikeda,
Nicola Crosetto,
Ivan Đikić
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.10.026
Subject(s) - biology , ubiquitin , signal transduction , genetics , computational biology , microbiology and biotechnology , gene
Ubiquitin signals and ubiquitin-binding domains are implicated in almost every cellular process, but how is their functionality achieved in cells? We assess recent advances in monitoring the dynamics and specificity of ubiquitin networks in vivo and discuss challenges ahead.
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