Open AccessMonocytes Join the Dendritic Cell Family
Author(s) -
Federica Sallusto,
Antonio Lanzavecchia
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.10.022
Subject(s) - biology , join (topology) , microbiology and biotechnology , dendritic cell , genetics , immune system , mathematics , combinatorics
Dendritic cells are professional antigen-presenting cells that mediate immunity and tolerance. Cheong et al. (2010) uncover a new route for dendritic cell production in vivo. They show that in response to infection by gram-negative bacteria, monocytes are recruited to the lymph node where they rapidly differentiate into dendritic cells that present antigens to T cells.
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