Cell Sorting during Regenerative Tissue Formation | Zendy

Rüdiger Klein | Zendy

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Cell Sorting during Regenerative Tissue Formation

Author(s) -

Rüdiger Klein

Publication year - 2010

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2010.09.018

Subject(s) - biology , sox2 , regeneration (biology) , microbiology and biotechnology , regenerative process , schwann cell , progenitor cell , cell sorting , ephrin , neuroscience , anatomy , cell , stem cell , signal transduction , transcription factor , genetics , gene

Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor Sox2, is required for nerve regeneration.

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