Open AccessHow the Sequence of a Gene Can Tune Its Translation
Author(s) -
Kurt Fredrick,
Michael Ibba
Publication year - 2010
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2010.03.033
Subject(s) - biology , translation (biology) , sequence (biology) , gene , genetics , ribosome , computational biology , protein biosynthesis , start codon , stop codon , encoding (memory) , base sequence , messenger rna , rna , neuroscience
Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.
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