Open AccessRNAi: Prokaryotes Get in on the Act
Author(s) -
John van der Oost,
Stan J. J. Brouns
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.11.018
Subject(s) - pyrococcus furiosus , biology , crispr , archaea , genetics , plasmid , rna , dna , computational biology , cas9 , rna interference , bacteria , gene
The small CRISPR-derived RNAs of bacteria and archaea provide adaptive immunity by targeting the DNA of invading viruses and plasmids. Hale et al. (2009) now report on a new variant CRISPR/Cas complex in the archaeon Pyrococcus furiosus that uses guide RNAs to specifically target and cleave RNA not DNA.
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