Regulating the Regulators: Posttranslational Modifications of RNA Silencing Factors | Zendy

Inha Heo | Zendy; V. Narry Kim | Zendy

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Regulating the Regulators: Posttranslational Modifications of RNA Silencing Factors

Author(s) -

Inha Heo,

V. Narry Kim

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.09.013

Subject(s) - biology , piwi interacting rna , rna induced silencing complex , gene silencing , argonaute , rna silencing , rasirna , regulator , trans acting sirna , rna induced transcriptional silencing , rna , microbiology and biotechnology , microrna , function (biology) , rna interference , computational biology , genetics , gene

Every regulator should be regulated, and this holds true for small RNAs and their associated proteins. Knowledge has begun to emerge of the various mechanisms that impose specificity on the expression and function of RNA silencing factors. Recent papers, including one in this issue of Cell (Paroo et al., 2009), now reveal the posttranslational modifications that take part in the regulation of the core RNA silencing factors, Ago, Piwi, and TRBP.

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