Structural Ties between Cholesterol Transport and Morphogen Signaling | Zendy

J. Fernando Bazán | Zendy; Frédéric J. de Sauvage | Zendy

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Structural Ties between Cholesterol Transport and Morphogen Signaling

Author(s) -

J. Fernando Bazán,

Frédéric J. de Sauvage

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.09.006

Subject(s) - biology , morphogen , cholesterol , microbiology and biotechnology , signal transduction , computational biology , genetics , biochemistry , gene

The molecular details of how cholesterol exits lysosomes and is integrated into cellular and endoplasmic reticulum membranes remain unclear. Two proteins implicated in this exit process, the 13-transmembrane transporter NPC1 and secreted NPC2, are known to be mutated in Niemann-Pick type C (NPC) disease in humans, characterized by cholesterol accumulation. A recent X-ray crystallographic study in Cell (Kwon et al., 2009) proposes an ingenious “hand-off” mechanism between the cholesterol-scavenging NPC2 protein and the membrane-bound NPC1.

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