Open AccessIKKɛ: A Bridge between Obesity and Inflammation
Author(s) -
Jerrold M. Olefsky
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.08.018
Subject(s) - biology , inflammation , insulin resistance , obesity , type 2 diabetes , iκb kinase , diabetes mellitus , bioinformatics , immunology , medicine , endocrinology , nf κb
Obesity leads to tissue inflammation and insulin resistance, which are features of metabolic diseases such as type 2 diabetes. Chiang et al. (2009) now show that the IkappaB kinase IKKepsilon is an important link between obesity and inflammation and may be a new therapeutic target for treating obesity-related metabolic diseases.
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