Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution | Zendy

Mark Shackleton | Zendy; Elsa Quintana | Zendy; Eric R. Fearon | Zendy; Sean J. Morrison | Zendy

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Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

Author(s) -

Mark Shackleton,

Elsa Quintana,

Eric R. Fearon,

Sean J. Morrison

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.08.017

Subject(s) - biology , cancer stem cell , carcinogenesis , cancer , somatic evolution in cancer , epigenetics , stem cell , cancer cell , epigenesis , cancer research , genetics , computational biology , dna methylation , gene , gene expression

The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant cells. To achieve this goal it will be necessary to determine which cancers follow a cancer stem cell model and which do not, to address technical issues related to tumorigenesis assays, and to test the extent to which cancer cell heterogeneity arises from genetic versus epigenetic differences.

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