Open AccessDNA Makes RNA Makes Innate Immunity
Author(s) -
Luke O'neill
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.07.021
Subject(s) - biology , innate immune system , dna , immunity , rna , interferon , rig i , cytosol , microbiology and biotechnology , virology , immune system , immunology , gene , genetics , enzyme , biochemistry
Microbial DNA in the cytosol induces production of interferon-beta (IFN-beta) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-beta production and innate immunity.
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