Open AccessNavigating the Deubiquitinating Proteome with a CompPASS
Author(s) -
Peter K. Jackson
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.07.008
Subject(s) - deubiquitinating enzyme , ubiquitin , biology , ubiquitin ligase , proteome , proteasome , computational biology , biochemistry , microbiology and biotechnology , gene
Deubiquitinating enzymes (DUBs) act on ubiquitinated substrates to regulate their modification and stability. In this issue, Sowa et al. (2009) present a comprehensive proteomic analysis of DUB interacting proteins in humans and a new quantitative scoring system for hits (CompPASS), providing a resource that links DUBs to biological pathways.
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