Open AccessA New Therapeutic Target for Leukemia Comes to the Surface
Author(s) -
David Ritchie,
Mark J. Smyth
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.07.005
Subject(s) - biology , cd47 , phagocytosis , myeloid leukemia , leukemia , cancer research , macrophage , stem cell , immunology , cell , myeloid , microbiology and biotechnology , biochemistry , in vitro
Expression of the cell-surface protein CD47 allows some normal cells to avoid phagocytosis by macrophages. In this issue, Jaiswal et al. (2009) and Majeti et al. (2009) show that elevated CD47 expression by leukemic stem cells inhibits macrophage activity and is an indicator of poor prognosis for patients with acute myeloid leukemia.
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