Open AccessTeeing Up Transcription on CpG Islands
Author(s) -
Harinder Singh
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.06.028
Subject(s) - biology , cpg site , transcription (linguistics) , genetics , computational biology , evolutionary biology , microbiology and biotechnology , dna methylation , gene , gene expression , linguistics , philosophy
Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al., 2009; Hargreaves et al., 2009).
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