Open AccessChromatin Places Metabolism Center Stage
Author(s) -
Andreas G. Ladurner
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.06.025
Subject(s) - biology , chromatin , center (category theory) , metabolism , microbiology and biotechnology , genetics , computational biology , dna , biochemistry , chemistry , crystallography
Dynamic changes in histone and transcription factor acetylation modulate gene expression. A study in Science (Wellen et al., 2009) reports that changes in glucose metabolism alter the availability of acetyl-CoA, the essential cofactor for protein acetylation. These findings reveal a direct connection between central metabolism and mammalian gene expression.
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