Common Ancestry of the CENP-A Chaperones Scm3 and HJURP | Zendy

Luis SánchezPulido | Zendy; Alison L. Pidoux | Zendy; Chris P. Ponting | Zendy; Robin C. Allshire | Zendy

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Common Ancestry of the CENP-A Chaperones Scm3 and HJURP

Author(s) -

Luis SánchezPulido,

Alison L. Pidoux,

Chris P. Ponting,

Robin C. Allshire

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.06.010

Subject(s) - centromere , biology , kinetochore , microbiology and biotechnology , chromosome segregation , histone h3 , genetics , nucleosome , cell division , histone , chromosome , cell , dna , gene

The centromere is a unique chromosomal locus that ensures accurate segregation of chromosomes during cell division. The centromere supports assembly of a multiprotein complex called the kinetochore, which attaches to spindle microtubules. The kinetochore has specialized nucleosomes in which histone H3 is replaced by the centromere-specific H3 variant CENP-A/cenH3 (reviewed in Allshire and Karpen, 2008). Two recent papers in Cell (Dunleavy et al., 2009; Foltz et al., 2009) have identified a new protein partner for soluble human CENP-A called HJURP/hFLEG/FAKTS that promotes the incorporation of CENP-A at centromeres.

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