Bridging Physiology and Pathology in AD | Zendy

Dohoon Kim | Zendy; LiHuei Tsai | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Bridging Physiology and Pathology in AD

Author(s) -

Dohoon Kim,

LiHuei Tsai

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.05.042

Subject(s) - biology , pathological , neuroscience , bridging (networking) , disease , central nervous system , nervous system , pathology , medicine , computer network , computer science

The APP-processing pathway is a pathological component of Alzheimer's disease (AD), but there is no consensus regarding the physiological functions of APP and its products. Two studies (Nikolaev et al., 2009; Lauren et al., 2009) link the physiological and pathological aspects of APP processing. They show that the APP products, N-APP and Abeta42, are ligands for death receptor 6 and cellular prion protein, respectively, which are important in nervous system development and synaptic suppression.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research