Open AccessAt Loose Ends: Resecting a Double-Strand Break
Author(s) -
Kara A. Bernstein,
Rodney Rothstein
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.05.007
Subject(s) - homologous recombination , biology , non homologous end joining , dna repair , genome instability , homology directed repair , dna , dna damage , dna repair protein xrcc4 , genetics , microbiology and biotechnology , nucleotide excision repair
Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination.
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