Open AccessAbate and Switch: miR-145 in Stem Cell Differentiation
Author(s) -
Raghu R. Chivukula,
Joshua T. Mendell
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.04.059
Subject(s) - biology , sox2 , klf4 , embryonic stem cell , microrna , stem cell , gene silencing , cellular differentiation , microbiology and biotechnology , cell potency , rex1 , induced pluripotent stem cell , genetics , gene
MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program.
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