Open AccessThe CULt of Caspase-8 Ubiquitination
Author(s) -
Miklós Békés,
Guy S. Salvesen
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.04.052
Subject(s) - biology , ubiquitin , microbiology and biotechnology , caspase , caspase 8 , apoptosis , caspase 2 , caspase 3 , programmed cell death , biochemistry , gene
Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
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