SnapShot: MicroRNAs in Cancer | Zendy

Riccardo Spizzo | Zendy; Milena S. Nicoloso | Zendy; Carlo M. Croce | Zendy; George A. Calin | Zendy

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SnapShot: MicroRNAs in Cancer

Author(s) -

Riccardo Spizzo,

Milena S. Nicoloso,

Carlo M. Croce,

George A. Calin

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.04.040

Subject(s) - biology , snapshot (computer storage) , microrna , computational biology , cancer , genetics , gene , computer science , operating system

let-7 family (various) Downregulated in lung, breast, gastric, ovary, prostate and colon cancers, CLL, leiomyomas; miR-98 downregulated in head and neck cancer. Point mutation in let-7e transcript affects miRNA maturation. Repress cell proliferation and growth. let-7f promotes angiogenesis. Targets: CCND1, CDC25a, CDC34, CDK6, CRDBP, DICER, HMGA2, HOXA9, IMP-1, ITGB3, MYC, RAS, TLR4. SNP in K-RAS 3′ UTR (let-7a binding site) increases NSCLC risk (cancer predisposition). Low expression of let-7a-2 in lung and ovarian cancer and of let-7b in uveal melanoma (poor prognosis). let-7i affects chemotherapy potency. Intranasal delivery of let-7a reduces growth of Ras-induced mouse lung tumors.

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