Frodos Found: Behold the CENP-A “Ring” Bearers | Zendy

Barbara G. Mellone | Zendy; Weiguo Zhang | Zendy; Gary H. Karpen | Zendy

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Frodos Found: Behold the CENP-A “Ring” Bearers

Author(s) -

Barbara G. Mellone,

Weiguo Zhang,

Gary H. Karpen

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.04.035

Subject(s) - centromere , biology , chromosome segregation , kinetochore , genetics , chromosome , histone , microbiology and biotechnology , evolutionary biology , dna , gene

CENP-A is a histone H3-like protein specific to centromeres that is essential for kinetochore formation and accurate chromosome segregation in eukaryotes. Recent studies (Dunleavy et al., 2009; Foltz et al., 2009; Perpelescu et al., 2009; Pidoux et al., 2009; Williams et al., 2009) analyze CENP-A binding proteins required for the recruitment of CENP-A to centromeres in humans and in fission yeast, bringing us closer to understanding how centromere identity is faithfully propagated.

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