Open AccessFallen Immortals
Author(s) -
Tomek Swigut,
Joanna Wysocka
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.04.008
Subject(s) - biology , somatic cell , epigenetics , chromatin , germline , histone , genetics , germ cell , demethylase , multicellular organism , microbiology and biotechnology , gene
The memory of somatic cell gene expression is reset in the germline in a process that is accompanied by dramatic changes in chromatin modifications. In this issue, Katz et al. (2009) show that the histone demethylase Lsd1/Spr-5 may participate in this resetting process in the worm, thereby preventing a decline in germ cell epigenetic stability and viability over ensuing generations.
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