Open AccessUbiquitin Connects with Planar Cell Polarity
Author(s) -
Marek Mlodzik
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.04.002
Subject(s) - biology , ubiquitin , microbiology and biotechnology , polarity (international relations) , planar , cell , ubiquitin protein ligases , cell polarity , ubiquitin ligase , computational biology , genetics , gene , computer science , computer graphics (images)
Planar cell polarity (PCP) regulates the orientation of cells in epithelia and of mesenchymal cells during gastrulation. In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry.
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