Open Accessβ-tting on p63 as a Metastatic Suppressor
Author(s) -
John G. Clohessy,
Pier Paolo Pandolfi
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.03.028
Subject(s) - biology , suppressor , metastasis , metastasis suppressor gene , metastasis suppressor , cancer research , mechanism (biology) , cancer , gene , genetics , philosophy , epistemology
Although much is known about the genes that promote metastasis, few suppressors of metastasis have been found. Adorno et al. (2009) now identify p63 as a potent suppressor of metastasis and uncover an intricate mechanism for the inactivation of metastasis in cancer cells in response to transforming growth factor beta.
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