Open AccessTRIM-NHL Proteins Take on miRNA Regulation
Author(s) -
Inga Loedige,
Witold Filipowicz
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.02.030
Subject(s) - biology , microrna , argonaute , translation (biology) , untranslated region , drosha , effector , gene , genetics , three prime untranslated region , function (biology) , microbiology and biotechnology , rna , computational biology , messenger rna , rna interference
The TRIM-NHL family of proteins is conserved among metazoans and has been shown to regulate cell proliferation and development. In this issue, Hammell et al. (2009) and Schwamborn et al. (2009) identify two members of this protein family, NHL-2 in worms and TRIM32 in mice, as positive regulators of microRNA function.
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