Transcriptional Scaffolds for Heterochromatin Assembly | Zendy

Hugh P. Cam | Zendy; Ee Sin Chen | Zendy; Shiv I. S. Grewal | Zendy

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Transcriptional Scaffolds for Heterochromatin Assembly

Author(s) -

Hugh P. Cam,

Ee Sin Chen,

Shiv I. S. Grewal

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.02.004

Subject(s) - heterochromatin , biology , chromatin , heterochromatin protein 1 , histone , euchromatin , transcription (linguistics) , dna methylation , constitutive heterochromatin , microbiology and biotechnology , genetics , dna , gene expression , gene , linguistics , philosophy

Heterochromatin is dynamically regulated during the cell cycle and in response to developmental signals. Recent findings from diverse systems suggest an extensive role for transcription in the assembly of heterochromatin, highlighting the emerging theme that transcription and noncoding RNAs can provide the initial scaffold for the formation of heterochromatin, which serves as a versatile recruiting platform for diverse factors involved in many cellular processes.

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