Fidelity at the Molecular Level: Lessons from Protein Synthesis | Zendy

Hani Zaher | Zendy; Rachel Green | Zendy

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Fidelity at the Molecular Level: Lessons from Protein Synthesis

Author(s) -

Hani Zaher,

Rachel Green

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2009.01.036

Subject(s) - translation (biology) , ribosome , fidelity , transfer rna , biology , computational biology , genetic code , shine dalgarno sequence , selection (genetic algorithm) , protein biosynthesis , t arm , ribosome profiling , genetics , computer science , rna , artificial intelligence , messenger rna , gene , telecommunications

The faithful and rapid translation of genetic information into peptide sequences is an indispensable property of the ribosome. The mechanistic understanding of strategies used by the ribosome to achieve both speed and fidelity during translation results from nearly a half century of biochemical and structural studies. Emerging from these studies is the common theme that the ribosome uses local as well as remote conformational switches to govern induced-fit mechanisms that ensure accuracy in codon recognition during both tRNA selection and translation termination.

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