Open AccessAn Amino Acid Shuffle Activates mTORC1
Author(s) -
Adiel Cohen,
Michael N. Hall
Publication year - 2009
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2009.01.021
Subject(s) - mtorc1 , glutamine , biology , leucine , amino acid , serine , cell growth , microbiology and biotechnology , biochemistry , pi3k/akt/mtor pathway , signal transduction , phosphorylation
The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.
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