When Sirtuins and NF-κB Collide | Zendy

Gioacchino Natoli | Zendy

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When Sirtuins and NF-κB Collide

Author(s) -

Gioacchino Natoli

Publication year - 2009

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2008.12.034

Subject(s) - biology , sirt6 , sirtuin , sirtuin 1 , transcription factor , gene expression , inflammation , gene , microbiology and biotechnology , nf κb , nfkb1 , transcription (linguistics) , regulation of gene expression , genetics , signal transduction , downregulation and upregulation , acetylation , immunology , linguistics , philosophy

Both the sirtuins and certain transcription factors of the NF-kappaB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-kappaB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.

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