Open AccessTracing the Retrograde Route in Protein Trafficking
Author(s) -
Ludger Johannes,
Vincent Popoff
Publication year - 2008
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2008.12.009
Subject(s) - biology , tracing , computational biology , microbiology and biotechnology , computer science , operating system
Retrograde transport, in which proteins and lipids are shuttled between endosomes and biosynthetic/secretory compartments such as the Golgi apparatus, is crucial for a diverse range of cellular functions. Mechanistic studies that explore the molecular machinery involved in this retrograde trafficking route are shedding light on the functions of transport proteins and are providing fresh insights into possible new therapeutic directions.
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