Open AccessMitofusin 2 Builds a Bridge between ER and Mitochondria
Author(s) -
Carsten Merkwirth,
Thomas Langer
Publication year - 2008
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2008.12.005
Subject(s) - mfn2 , endoplasmic reticulum , mitochondrion , biology , mitochondrial fusion , microbiology and biotechnology , gtpase , biochemistry , mitochondrial dna , gene
Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.
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