SnapShot: The Human DNA Methylome in Health and Disease | Zendy

Esteban Ballestar | Zendy; Manel Esteller | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

SnapShot: The Human DNA Methylome in Health and Disease

Author(s) -

Esteban Ballestar,

Manel Esteller

Publication year - 2008

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2008.11.040

Subject(s) - biology , snapshot (computer storage) , dna methylation , computational biology , genetics , dna , disease , gene , computer science , gene expression , medicine , pathology , operating system

The essential role of DNA methylation in X chromosome inactivation and imprinting is widely recognized, but we know little about tissue-specific DNA methylation or DNA methylation changes in regulatory regions. Several international epigenome projects, including the Human Epigenome Project, plan to generate detailed maps of DNA methy-lation in normal cells and cells that are altered during disease pathogenesis. The SnapShot shows a summary of our current knowledge of the DNA methylation patterns in normal human cells and in human cells in different disease states. In normal cells, DNA methylation is restricted to a few tissue-specific genes (white arrow heads) and imprinted genes (gray arrow heads) and throughout the inactive X (X

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research