Open AccessDivided within: Heterogeneity within Adult Stem Cell Pools
Author(s) -
Marc H.G.P. Raaijmakers,
David T. Scadden
Publication year - 2008
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2008.11.034
Subject(s) - biology , stem cell , microbiology and biotechnology , evolutionary biology , genetics
In this issue, Wilson et al. (2008) demonstrate that there are two functional subsets of hematopoietic stem cells that have distinctive kinetics of cell cycling. They present evidence that cells may transition between the two kinetic states, establishing one subpopulation that is ready to proliferate and another that is a deeply quiescent reserve.
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